# Semax Research — Full Context > Semax nootropic peptide research — ACTH(4-10) analog, BDNF upregulation, neuroprotection, stroke recovery, cognitive enhancement mechanisms, and gene expression studies with PubMed citations. ## About This Site Semax Research is part of the System Peptides Research Network — a collection of 21 specialized peptide research resources. Each site focuses on a specific compound or research area, providing peer-reviewed content sourced exclusively from PubMed-indexed publications. This site is an educational resource and does not sell products directly. Research-grade peptides are available at researchvials.com. ## Site Identity - Domain: https://semax-research.com - Network: System Peptides Research Network - Parent Store: https://researchvials.com - Wikidata: https://www.wikidata.org/wiki/Q139376131 - ORCID: https://orcid.org/0009-0004-9811-6147 ## Research Focus Peptides ### Semax (Semax, ACTH(4-7)-PGP, Heptapeptide Semax) - CAS: 80714-61-0 - Molecular Weight: 813.93 g/mol - Sequence: Met-Glu-His-Phe-Pro-Gly-Pro - Mechanism: Semax is a synthetic heptapeptide based on ACTH(4-7) (the fragment Met-Glu-His-Phe from adrenocorticotropic hormone) with an added Pro-Gly-Pro C-terminal extension for metabolic stability. Developed at the Institute of Molecular Genetics of the Russian Academy of Sciences alongside selank, semax is ... - Research Areas: Nootropic Research, Neuroprotection, BDNF Expression, Stroke Recovery Key Findings: - - - - ## Site Pages - Home: https://semax-research.com/ - Research Profiles: https://semax-research.com/research/ - Articles: https://semax-research.com/articles/ - FAQ: https://semax-research.com/faq/ - COA Guide: https://semax-research.com/coa-guide/ - About: https://semax-research.com/about/ - Research Calculator (88+ protocols, dosing phases, mechanisms of action, syringe visualization, FAQs): https://semax-research.com/tools/dosing-calculator/ - Privacy Policy: https://semax-research.com/privacy/ - Accessibility Statement: https://semax-research.com/accessibility/ - Cookie Policy: https://semax-research.com/cookies/ - Disclaimer: https://semax-research.com/disclaimer/ ## Articles ### Essential Peptides for Anti-Aging and Longevity Research URL: https://semax-research.com/articles/essential-peptides-anti-aging-longevity-research/ ### AI and Peptide Discovery: How Machine Learning Is Changing Research URL: https://semax-research.com/articles/ai-peptide-discovery-machine-learning-research/ ### Peptide Research Trends to Watch in 2026 URL: https://semax-research.com/articles/peptide-research-trends-2026/ ## Research Applications - Cognitive Enhancement: Boosts BDNF (brain-derived neurotrophic factor) to improve memory, cognitive performance under stress, and learning speed. Modulates serotonergic, dopaminergic, and cholinergic systems. - Neuroprotection: In ischemic stroke models, Semax reduces infarct volume, improves neurological outcomes, and modulates the post-stroke inflammatory cascade. Shows effects in oxidative stress models. - Gene Expression: Semax modulates expression of hundreds of genes involved in neuronal survival, synaptic plasticity, and neurotransmitter metabolism — with broad transcriptional effects in brain tissue. ## Frequently Asked Questions Q: What is Semax? A: Semax is a synthetic heptapeptide analog of ACTH(4-10) — the fragment of adrenocorticotropic hormone responsible for nootropic activity. It has a C-terminal Pro-Gly-Pro extension that increases stability. Developed at the Institute of Molecular Genetics in Moscow, it is approved in Russia for stroke... Q: How does Semax enhance cognition in research? A: Semax upregulates BDNF (brain-derived neurotrophic factor) and its receptor TrkB in the hippocampus and cortex. It also modulates expression of hundreds of genes involved in neuronal survival, synaptic plasticity, and neurotransmitter metabolism — affecting serotonergic, dopaminergic, and cholinergi... Q: What neuroprotective effects has Semax shown? A: In ischemic stroke models, Semax reduces infarct volume, improves neurological outcomes, and modulates the post-stroke inflammatory cascade. It also shows neuroprotective effects in oxidative stress models and neurodegenerative disease research. ## Interactive Tools - Research Calculator: https://semax-research.com/tools/dosing-calculator/ 88+ peptide protocols with reconstitution calculator, dosing phases, mechanism of action, half-life data, administration guidance, side effects, compatible stacks, per-protocol FAQs, and interactive syringe visualization. Supports blends with per-component injection breakdowns. ## Research Network (Sister Sites) - Epitalon Research (epitalon-research.com): Epitalon Telomerase Research — Longevity & Pineal Bioregulation - Selank Research (selank-research.com): Selank Anxiolytic Peptide Research — BDNF & Immune Modulation - NAD+ Research (nadplus-research.com): NAD+ Cellular Energy Research — Sirtuins, DNA Repair & Longevity - Pinealon Research (pinealonresearch.com): Pinealon Bioregulator Research — Neuroprotection & Circadian Science - RETA Research (reta-research.com): RETA Peptide Research — Comprehensive Peptide Science & Analysis ## Quality Standards - All peptides referenced are 98%+ purity, HPLC verified - Independent third-party Certificates of Analysis (COAs) available - 100% USA-based: managed, tested, and shipped domestically - Cold-chain shipping with temperature-controlled logistics - Peer-reviewed content with direct PubMed citations ## Content Policy All content is for educational and research purposes only. Products referenced are for laboratory research use only (Research Use Only — RUO). Not approved by the FDA for human consumption, veterinary use, or any therapeutic purpose. All references to research findings describe preclinical laboratory studies, not clinical recommendations. Consult a licensed healthcare provider for any medical questions. ## Feeds - RSS/Atom: https://semax-research.com/feed.xml - JSON Feed: https://semax-research.com/feed.json ## Structured Data This site implements schema.org markup including Organization, WebSite, WebPage, Person, BreadcrumbList, FAQPage, SpeakableSpecification, and BlogPosting schemas with sameAs links to Wikidata, ORCID, and authority profiles. ## AI & Machine Readability - llms.txt: https://semax-research.com/llms.txt - llms-full.txt: https://semax-research.com/llms-full.txt - Agent Card: https://semax-research.com/.well-known/agent-card.json - AI Plugin: https://semax-research.com/.well-known/ai-plugin.json - Security: https://semax-research.com/.well-known/security.txt - Sitemap: https://semax-research.com/sitemap.xml - Robots: https://semax-research.com/robots.txt