Semax Nootropic Neuropeptide Research
Semax nootropic peptide research — ACTH(4-10) analog, BDNF upregulation, neuroprotection, stroke recovery, cognitive enhancement mechanisms, and gene expression studies with PubMed citations.
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In-depth research profiles with mechanisms of action, key findings, and peer-reviewed citations.
Semax
Also known as: Semax, ACTH(4-7)-PGP, Heptapeptide Semax
Semax is a synthetic heptapeptide based on ACTH(4-7) (the fragment Met-Glu-His-Phe from adrenocorticotropic hormone) with an added Pro-Gly-Pro C-terminal extension for metabolic stability. Developed at the Institute of Molecular Genetics of the Russian Academy of Sciences alongside selank, semax is approved in Russia as a nootropic and neuroprotective medication. Semax does not activate the melan...
Quick Facts
Sequence: Met-Glu-His-Phe-Pro-Gly-Pro
MW: 813.93 g/mol
CAS: 80714-61-0
Store lyophilized powder at -20C. Reconstituted solution at 2-8C, use within 14-21 days. The Pro-Gly-Pro extension provi...
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Read ArticleResearch Applications
Key research categories and applications studied in the scientific literature.
Cognitive Enhancement
Boosts BDNF (brain-derived neurotrophic factor) to improve memory, cognitive performance under stress, and learning speed. Modulates serotonergic, dopaminergic, and cholinergic systems.
Neuroprotection
In ischemic stroke models, Semax reduces infarct volume, improves neurological outcomes, and modulates the post-stroke inflammatory cascade. Shows effects in oxidative stress models.
Gene Expression
Semax modulates expression of hundreds of genes involved in neuronal survival, synaptic plasticity, and neurotransmitter metabolism — with broad transcriptional effects in brain tissue.
Frequently Asked Questions
Common questions about semax research research, purity standards, and sourcing.
What is Semax?
Semax is a synthetic heptapeptide analog of ACTH(4-10) — the fragment of adrenocorticotropic hormone responsible for nootropic activity. It has a C-terminal Pro-Gly-Pro extension that increases stability. Developed at the Institute of Molecular Genetics in Moscow, it is approved in Russia for stroke and cognitive disorders.
How does Semax enhance cognition in research?
Semax upregulates BDNF (brain-derived neurotrophic factor) and its receptor TrkB in the hippocampus and cortex. It also modulates expression of hundreds of genes involved in neuronal survival, synaptic plasticity, and neurotransmitter metabolism — affecting serotonergic, dopaminergic, and cholinergic systems.
What neuroprotective effects has Semax shown?
In ischemic stroke models, Semax reduces infarct volume, improves neurological outcomes, and modulates the post-stroke inflammatory cascade. It also shows neuroprotective effects in oxidative stress models and neurodegenerative disease research.
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